{"id":290,"date":"2017-04-08T22:22:22","date_gmt":"2017-04-08T22:22:22","guid":{"rendered":"https:\/\/seniorfitness.blog\/?p=290"},"modified":"2017-04-09T07:17:43","modified_gmt":"2017-04-09T07:17:43","slug":"dr-paul-offit-vs-kosttilskud-mod-slidgigt","status":"publish","type":"post","link":"https:\/\/seniorfitness.blog\/?p=290","title":{"rendered":"Dr. Paul Offit vs kosttilskud mod slidgigt"},"content":{"rendered":"

I bogen Killing us Softly: The\u00a0Sense and Nonsense of Alternative Medicine\u00a0<\/em>langer forfatteren\u00a0Dr.\u00a0Paul Offit ud efter alternative behandlere og producenter af ‘naturlige’ kosttilskud, der g\u00e5r\u00a0under alternativ medicin –\u00a0en institution som\u00a0l\u00e6ner sig op af empiriske indtryk, l\u00f8se postulater og pseudovidenskabelige forklaringer af virkningsmekanismer\u00a0ved behandlinger og pr\u00e6parater.<\/p>\n

Dr. Paul Offit er en velanset b\u00f8rnel\u00e6ge med speciale i infektionssygdomme, og har v\u00e6ret med til at udvikle en virusvaccine, der efter sigende har reddet rigtig mange liv. Han er\u00a0fortaler for b\u00f8rnevaccineprogrammer, og har op til\u00a0flere gange afvist, at der er en sammenh\u00e6ng mellem vacciner og risiko for udvikling af autisme.<\/p>\n

N\u00e5r\u00a0Dr. Offit\u00a0i sin bog stiller sp\u00f8rgsm\u00e5lstegn ved osteopaten Rashid Buttars fremgangsmetoder ved behandling af autisme og kr\u00e6ft ved at chelere tungmetaller i kroppen virker det overbevisende.\u00a0I bogen tager han ogs\u00e5 fat p\u00e5 andre emner, som akupunktur og kosttilskud\u00a0til behandling af slidgigt. Og n\u00e5r han afviser disse som virkningsl\u00f8se,\u00a0virker det n\u00e6rliggende, at han nok ogs\u00e5 har ret i det.<\/p>\n

So I went to a health food store and bought saw palmetto, chondroitin sulfate, and glucosamine. But before I took them, I looked to see whether studies had been done showing they worked. The studies were large, internally consistent, well controlled, and rigorously performed. And the results were clear: saw palmetto didn’t shrink prostates, and chondroitin sulfate and glucosamine didn’t treat joint pain.<\/p>\n

– Dr. Offit om sine handlinger efter bekendte havde givet ham gode r\u00e5d om at tage kosttilskud for en forst\u00f8rret prostata og kn\u00e6smerter<\/p><\/blockquote>\n

\"\"
Dr. Paul Offit. Fra Wikipedia.org<\/figcaption><\/figure>\n

Hvad ang\u00e5r den manglende virkning af chondroitinsulfat og glucosamin vender han sig mod den videnskabelige litteratur. I bogen h\u00e6fter han sig ved et enkelt studie publiceret i 2006, hvor 1500 personer fik glucosamin og chondroitinsulfat hver for sig eller sammen, sammenlignet med et anti-inflammatorisk pr\u00e6parat eller placebo. I dette studie var det kun det medicinske pr\u00e6parat, der viste en effekt. P\u00e5 denne baggrund har Dr. Offit smidt glucosamin og chondroitinsulfat\u00a0hen i bunken af kosttilskud,\u00a0der kan kategoriseres som kvaksalveri.<\/p>\n

Ved et lidt n\u00e6rmere gennemsyn er Dr. Offits\u00a0kolde skulder\u00a0til alternativ behandling af slidgigt dog ikke helt retf\u00e6rdig. Flere metaanalyser (analyser, hvor flere videnskabelige studier sammenholdes for at unders\u00f8ge om et resultat har statistisk signifikans) peger p\u00e5, at b\u00e5de chondroitinsulfat og glycosamin alene eller i kombination kan have\u00a0en moderat lindrende effekt p\u00e5 smerter i forbindelse med slidgigt. Nogle studier viser endda en strukturel effekt (st\u00f8rre afstand mellem modst\u00e5ende knogler i et led) i forhold til placebo.<\/p>\n

Nogle af metaanalyserne er udf\u00f8rt efter udgivelsen af Killing Us Softly i 2013<\/em>, men andre metaanalyser, og\u00a0en lang r\u00e6kke af de originale studier er udf\u00f8rt\u00a0tidligere.\u00a0Det giver mulighed for to forklaringer: 1) Dr.\u00a0Offit havde lidt travlt med at lave research til sin bog\u00a0og kom uagtsomt til at overse de mange studier, som peger p\u00e5 at alternativ behandling af slidgigt kan have en lige s\u00e5 god effekt, som det anti-inflammatoriske pr\u00e6parat han henviser til – eller 2)\u00a0Den positive konklusion omkring chondroitinsulfat\/glycosamin\u00a0passede ikke ind i Dr. Offits historie\u00a0om\u00a0alternative behandleres promovering af virkningsl\u00f8se pr\u00e6parater.<\/p>\n

Man kan naturligvis kun gisne om, hvilken af de to, der passer…<\/p>\n

Dette kan naturligvis f\u00e5 \u00e9n til at stille sp\u00f8rgsm\u00e5lstegn ved andre konklusioner som Dr. Offit n\u00e5r frem til i sin bog. Om det er berettiget eller ej skal jeg ikke kunne sige, men som en person, der stikker n\u00e6sen frem med klare meninger i sp\u00f8rgsm\u00e5l, der deler vandene har han m\u00f8dt en del kritik i sit hjemland, USA.\u00a0Blandt andet har der v\u00e6ret fokus p\u00e5, at han\u00a0har v\u00e6ret fortaler for udvidelsen af bestemte vaccinationsprogrammer\u00a0og samtidig selv at have \u00f8konomiske interesser i det.<\/p>\n

Under alle omst\u00e6ndigheder er pointen, at det er en god id\u00e9 at forholde sig kritisk til udsagn om, hvorvidt noget virker eller ej. Og det g\u00e6lder alts\u00e5 ogs\u00e5 for personer med en medicinsk baggrund – s\u00e6rligt hvis de har en agenda.<\/p>\n

 <\/p>\n

\n

Kilder:<\/p>\n

Paul Offit<\/a>. Wikipedia.org. 10.3.2017<\/p>\n

Vaccine Doctor Given at Least $30 Million Dollars to Push Vaccines?<\/a> Mercola.com, 25.6.2009<\/p>\n

Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration.<\/a>\u00a0<\/b>Hochberg MC. Osteoarthritis Cartilage<\/span>. 2010 Jun;18 Suppl 1:S28-31. doi: 10.1016\/j.joca.2010.02.016. Review.<\/p>\n

Symptom-modifying effect of chondroitin sulfate in knee osteoarthritis: a meta-analysis of randomized placebo-controlled trials performed with structum(\u00ae).<\/a>\u00a0<\/b>Schneider H, Maheu E, Cucherat M. Open Rheumatol J<\/span>. 2012;6:183-9. doi: 10.2174\/1874312901206010183.<\/p>\n

Chondroitin for osteoarthritis.<\/a>\u00a0Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Cochrane Database Syst Rev<\/span>. 2015 Jan 28;1:CD005614. doi: 10.1002\/14651858.CD005614.pub2. Review.<\/p>\n

Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee.<\/a>\u00a0Zeng C, Wei J, Li H, Wang YL, Xie DX, Yang T, Gao SG, Li YS, Luo W, Lei GH. Sci Rep<\/span>. 2015 Nov 18;5:16827. doi: 10.1038\/srep16827.<\/p>\n

Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib.<\/a>\u00a0<\/b>Hochberg MC, Martel-Pelletier J, Monfort J, M\u00f6ller I, Castillo JR, Arden N, Berenbaum F, Blanco FJ, Conaghan PG, Dom\u00e9nech G, Henrotin Y, Pap T, Richette P, Sawitzke A, du Souich P, Pelletier JP; MOVES Investigation Group. Ann Rheum Dis<\/span>. 2016 Jan;75(1):37-44. doi: 10.1136\/annrheumdis-2014-206792.<\/p>\n

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